Bruch's membrane

Hyaline bodies may be found in the optic disc and in several parts of the retina as a nonspecific finding (Wolter, 1959). The term drusen ("colloid bodies") is usually reserved for large hyaline bodies of the optic disc and Bruch's membrane. Lorentzen (I966), postulated that drusen of the optic disc had an irregular dominant pattern of inheritance after an examination of the relatives of 49 affected individuals. Drusen of Bruch's membrane are found in several degenerative conditions and systemic diseases and are often a senile manifestation (Duke-Elder, I967). Not infrequently, however, they are the result of a primary hereditary dystrophy, usually transmitted as a regular dominant trait.